Beilstein J. Org. Chem.2011,7, 1198–1204, doi:10.3762/bjoc.7.139
for the direct synthesis of functionalized γ-vinylbutyrolactones by intramolecularoxaallylicalkylation with primary alcohols. Good isolated chemical yields were obtained for a range of malonyl and acetate derivatives. The good performance in reagent-grade solvents and the functional group/moisture
tolerance make this catalytic process a promising route for the synthesis of architecturally complex polycyclic structures.
Keywords: alcohol; butyrolactone; carbene; gold-catalysis; intramolecularoxaallylicalkylation; Introduction
Allylic alcohols are highly desirable, readily available, cheap, and
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Graphical Abstract
Figure 1:
Working hypothesis for the present gold-catalyzed oxaallylic alkylation reaction.